Division of Pharmacology and Toxicology Department of Pharmacy University of Helsinki ROLE OF NICOTINIC ACETYLCHOLINE RECEPTORS IN CEREBRAL DOPAMINERGIC TRANSMISSION AND EXPRESSION OF FOS PROTEIN
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چکیده
Cigarette smoking is the most widespread form of drug abuse due to the addictive properties of nicotine present in tobacco. Via binding to specific receptors, known as nicotinic acetylcholine receptors (nAChRs), nicotine activates the mesolimbic dopamine (DA) system, which is hypothesised to be the final common pathway shared by rewarding stimuli in the brain. In addition to the mesolimbic dopaminergic system, nicotine also targets the nigrostriatal DA system along with several other neurotransmitter systems in the brain, and it is the convergence of these different stimuli that most probably contributes to the pharmacological effects of
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